Metabolomic Medicine: Studies And Research
Fathoming Metabolism
Harvard Magazine / 2011
Abstract
The study of metabolites does an end run around genomics to provide telling clues to your future health. Metabolites not only reveal much about your current health—how well you burn fats or how deep you can dig when exerting yourself physically—but can provide hints of what’s to come. Research on the major metabolic killers—diabetes, kidney disease, and heart disease—reveals critical signs of systemic dysfunction at the molecular level years before clinical symptoms appear. FULL STUDY
Metabolomics: What’s Happening Downstream of DNA
Environews / 2004
Abstract
Whereas genes and proteins set the stage for what happens in the cell, much of the actual activity is at the metabolite level: cell signaling, energy transfer, and cell-to-cell communication are all regulated by metabolites. Furthermore, gene and protein expression are closely linked, but metabolite behavior more closely reflects the actual cellular environment, which is itself dependent on nutrition, drug and pollutant exposures, and other exogenous factors that influence health.
Application of metabolomics in autoimmune diseases: Insight into biomarkers and pathology
Journal Of Autoimmunology / 2015
Abstract
Metabolomics has recently become a new technology using mass spectrometry (MS) and high-resolution proton nuclear magnetic resonance (NMR) to access metabolite profiles in biofluids or tissue extracts for the detection of biomarker molecules and biochemical effects induced by a disease or its therapeutic intervention. This review outlines recent advances in the use of metabolomic techniques to study autoimmune diseases (ADs), including multiple sclerosis (MS), rheumatoid arthritis (RA), inflammatory bowel diseases (IBD), autoimmune diabetes et al. Many studies have demonstrated that AD patients including subtypes of some diseases, and healthy individuals can be distinguished using metabolic profiling accompanied with well-established data analysis tools including principal component analysis (PCA) and partial least squares (PLS). These metabolites not only affect glucose, amino acid and lipid metabolism, but also involve alteration of neurotransmitters, nucleotides, immune responses and anti-inflammatory responses. Knowledge of unique metabolomic fingerprint in ADs could be useful for diagnosis, treatment, and detection mechanisms of diseases.
Metabolomics and Exercise: possibilities and perspectives
Universidade Estadual de Campinas / 2017
Abstract
The possibilities of using metabolomics approach are increasing in the fields of Health Sciences, Sports, and Physical Activity. The experimental design of the study is essential to take advantage of this tool and be able to answer questions in the metabolism comprehension. There is an exponential increase of the use of metabolomics in researches over the last 16 years.
Applications of metabolomics in cancer research
Journal of Carcinogenesis / 2013
Metabolomics holds great promise for advancing the understanding, diagnosis, and treatment of cancer. The approach has already been used to uncover and verify mechanisms of carcinogenesis and proliferation, identify numerous candidate diagnostic biomarkers in biofluid and biopsy samples, and even contribute to the staging of cancers and characterization of treatment efficacy – much of this before metabolomics analysis became more widely accessible to researchers via broader establishment of metabolomics core facilities.
Biomarkers Of Fatigue: Metabolomics Profiles Predictive of Cognitive Performance
Air Force Research Laboratory / 2012
Recent advances in our laboratory’s bioinformatics tools development for multivariate statistical analysis of NMR-based metabolomics data has resulted in more accurate biosignature and biomarker identification (Anderson et al. 2011). In the present study, bioinformatic analysis of NMR data indicated that urinary metabolite profiles could discern differences in cognitive performance of study subjects 12 h prior to cognitive testing, and of subjects that were sleep-deprived for 28 h.
Metabolomics: the apogee of the omic triology
Nature Reviews Molecular Cell Biology / 2012
Abstract
Metabolites, the chemical entities that are transformed during metabolism, provide a functional readout of cellular biochemistry. With emerging technologies in mass spectrometry, thousands of metabolites can now be quantitatively measured from minimal amounts of biological material, which has thereby enabled systems-level analyses. By performing global metabolite profiling, also known as untargeted metabolomics, new discoveries linking cellular pathways to biological mechanism are being revealed and shaping our understanding of cell biology, physiology, and medicine.
Application of metabolomics: Focus on the quantification of organic acids in healthy adults
International Journal of Molecular Medicine / 2017
Abstract
Metabolomics, a ‘budding’ discipline, may accurately reflect a specific phenotype which is sensitive to genetic and epigenetic interactions. This rapidly evolving field in science has been proposed as a tool for the evaluation of the effects of epigenetic factors, such as nutrition, environment, drug and lifestyle on phenotype.
CLICK HERE FOR FURTHER METABOLOMIC STUDIES
Fathoming Metabolism
Harvard Magazine / 2011
Abstract
The study of metabolites does an end run around genomics to provide telling clues to your future health. Metabolites not only reveal much about your current health—how well you burn fats or how deep you can dig when exerting yourself physically—but can provide hints of what’s to come. Research on the major metabolic killers—diabetes, kidney disease, and heart disease—reveals critical signs of systemic dysfunction at the molecular level years before clinical symptoms appear. FULL STUDY
Metabolomics: What’s Happening Downstream of DNA
Environews / 2004
Abstract
Whereas genes and proteins set the stage for what happens in the cell, much of the actual activity is at the metabolite level: cell signaling, energy transfer, and cell-to-cell communication are all regulated by metabolites. Furthermore, gene and protein expression are closely linked, but metabolite behavior more closely reflects the actual cellular environment, which is itself dependent on nutrition, drug and pollutant exposures, and other exogenous factors that influence health.
Application of metabolomics in autoimmune diseases: Insight into biomarkers and pathology
Journal Of Autoimmunology / 2015
Abstract
Metabolomics has recently become a new technology using mass spectrometry (MS) and high-resolution proton nuclear magnetic resonance (NMR) to access metabolite profiles in biofluids or tissue extracts for the detection of biomarker molecules and biochemical effects induced by a disease or its therapeutic intervention. This review outlines recent advances in the use of metabolomic techniques to study autoimmune diseases (ADs), including multiple sclerosis (MS), rheumatoid arthritis (RA), inflammatory bowel diseases (IBD), autoimmune diabetes et al. Many studies have demonstrated that AD patients including subtypes of some diseases, and healthy individuals can be distinguished using metabolic profiling accompanied with well-established data analysis tools including principal component analysis (PCA) and partial least squares (PLS). These metabolites not only affect glucose, amino acid and lipid metabolism, but also involve alteration of neurotransmitters, nucleotides, immune responses and anti-inflammatory responses. Knowledge of unique metabolomic fingerprint in ADs could be useful for diagnosis, treatment, and detection mechanisms of diseases.
Metabolomics and Exercise: possibilities and perspectives
Universidade Estadual de Campinas / 2017
Abstract
The possibilities of using metabolomics approach are increasing in the fields of Health Sciences, Sports, and Physical Activity. The experimental design of the study is essential to take advantage of this tool and be able to answer questions in the metabolism comprehension. There is an exponential increase of the use of metabolomics in researches over the last 16 years.
Applications of metabolomics in cancer research
Journal of Carcinogenesis / 2013
Metabolomics holds great promise for advancing the understanding, diagnosis, and treatment of cancer. The approach has already been used to uncover and verify mechanisms of carcinogenesis and proliferation, identify numerous candidate diagnostic biomarkers in biofluid and biopsy samples, and even contribute to the staging of cancers and characterization of treatment efficacy – much of this before metabolomics analysis became more widely accessible to researchers via broader establishment of metabolomics core facilities.
Biomarkers Of Fatigue: Metabolomics Profiles Predictive of Cognitive Performance
Air Force Research Laboratory / 2012
Recent advances in our laboratory’s bioinformatics tools development for multivariate statistical analysis of NMR-based metabolomics data has resulted in more accurate biosignature and biomarker identification (Anderson et al. 2011). In the present study, bioinformatic analysis of NMR data indicated that urinary metabolite profiles could discern differences in cognitive performance of study subjects 12 h prior to cognitive testing, and of subjects that were sleep-deprived for 28 h.
Metabolomics: the apogee of the omic triology
Nature Reviews Molecular Cell Biology / 2012
Abstract
Metabolites, the chemical entities that are transformed during metabolism, provide a functional readout of cellular biochemistry. With emerging technologies in mass spectrometry, thousands of metabolites can now be quantitatively measured from minimal amounts of biological material, which has thereby enabled systems-level analyses. By performing global metabolite profiling, also known as untargeted metabolomics, new discoveries linking cellular pathways to biological mechanism are being revealed and shaping our understanding of cell biology, physiology, and medicine.
Application of metabolomics: Focus on the quantification of organic acids in healthy adults
International Journal of Molecular Medicine / 2017
Abstract
Metabolomics, a ‘budding’ discipline, may accurately reflect a specific phenotype which is sensitive to genetic and epigenetic interactions. This rapidly evolving field in science has been proposed as a tool for the evaluation of the effects of epigenetic factors, such as nutrition, environment, drug and lifestyle on phenotype.
CLICK HERE FOR FURTHER METABOLOMIC STUDIES
Measurement of metabolites gives a precise pathway to permanent health by personalizing nutrition, micro-nutrition and lifestyle.
