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Metabolomics has an unprecedented track record in addressing and preventing chronic disease, achieving optimal weight, dramatically increasing overall energy levels, and by helping with gut biome, naturally dealing with mental issues like depression, anxiety, mental fog and overall cognitive performance.  Out of 15,000+ clients, more than 80 percent experienced transformative results within a 6-month period, with a 99 percent accuracy on test results.

Unlike conventional approaches that look for universal cures for any chronic condition, metabolomics focuses on the uniqueness of an individual’s metabolism. Technically, metabolomics is the study of metabolites, small molecules produced by chemical energy conversion reactions in our cells. Through new molecular scanning technology, it’s now possible to analyze the 5,000 different metabolites that are known to impact health, weight, energy, metabolism, and overall function of the human body. By determining the condition of each and their variance from what is normal, the analysis gives you deep insight into:

  • lack of vitamins and other essential elements within the cells
  • cellular function/malfunction
  • toxic burden
  • antioxidant status
  • nervous system functioning
  • condition of the intestinal flora
  • mitochondrial function
  • metabolism of proteins, carbohydrates, and fats
  • existing predisposition to inflammation
  • existence of acidosis or alkalosis
  • essential fatty acid balance (like omega 3 and omega 6)
  • insulin resistance and other vital indicators.

Some view the metabolomic approach as the ultimate in personalized medicine. Others see it as the missing link between conventional and alternative medical modalities. Any blockages, toxin accumulation, mitochondrial wear and tear, or nutritional deficiencies that show up as a marker in the final lab results are addressed both pharmacologically and nutraceutically.

“There are only two reasons for chronic disease,” says Dr. Dimitris Tsoukalas, founder of Metabolomic Medicine®. “One is lack of proper nutrients, the other is an accumulation of damage faster than the body’s ability to repair. We identify and address both by tracking your metabolites.”

Biological imbalances are then treated with special nutritional supplements, enzymes, amino acids, trace minerals, and vitamins. The patient also receives a personalized nutritional plan to replenish the deficiencies and restore biochemical imbalances at the cellular level.

“You cannot rebuild a biochemical balance by addressing just one deficiency,” says Tsoukalas, who likes to compare human biochemistry to a combustion engine. “You need fuel. A battery. A spark plug. A chain of functional parts for the car to move forward. If one step of the chain is off, the whole chain fails to function. The same goes for the human organism. We often have to rebuild entire pathways for the body to rebuild completely. Healing is not possible without addressing all the parts. It’s the whole or nothing.”

An examination of metabolites not only reveals your current health but also projects your future based on more than 15,000 case studies, data that is especially useful if you are taking the analysis for better preventative health.

Metabolomic Analysis is carried out in blood and urine samples and in collaboration with one of five top laboratories in the USA and Europe that exercise high technical standards. To carry out an exam, a lab must be certified by the European Research Network for Diagnosis ERNDIM . They are a scientific institution with the highest laboratory standards worldwide.

The Metabolomic Analysis Profile assesses:

  • Lipid metabolism
  • Nerve cell and neurotransmitter metabolism (substances transferring signals in the nervous system)
  • Carbohydrate metabolism (sugar, complex carbohydrates, fructose)
  • The oxidative condition and antioxidant mechanisms status
  • The lack or sufficiency  in vitamins and micronutrients
  • The condition of the intestinal flora of the body
  • Inflammation
  • The ability to detoxify and the toxic charge
  • The factors of DNA methylation (activation and functioning of genes)
  • Mitochondrial Dysfunction
  • Omega 3 and free fatty acids metabolism

Chronic Disease

With chronic disease rates rising dramatically, proper diagnosis and prevention is crucial. As a species, we’re living longer but are sicker than ever beforeA 2013 analysis from the Global Burden of Disease Study (GBD) points to an historic surge in chronic illness. Just one in 20 people worldwide are healthy today while one in three experience more than five ailments. The rapidly escalating variety and number of chronic illnesses is a modern scourge. There are now over 150 autoimmune conditions (58- 80 million cases in America alone) — counting just the ones that have been identified by modern medicine. Meanwhile, half of women and two-thirds of men will get cancer in their lifetime, with over 100 forms of cancer to pick and choose from. Then there is asthma, cardiovascular diseases, degenerative brain diseases like Alzheimer’s, and a wide spectrum of debilitating mental health conditions like depression. So what’s going on? Metabolomics points to four main factors that contribute to the surge in chronic illnesses over the last century:
  1. Nutrient-poor foods.
  2. Environmental factors such as pollution, pesticides, and sharp decline in oxygen.
  3. Dehydration (studies show two out of three people are partially dehydrated).
  4. Stress (mental, biological, physical).

Our food supply is especially low in nutrients and high in calories.

“The sharp decline of our food’s content in nutrients is vital to life and health and is the greatest problem we face today,” says Tsoukalas. “Most of the food we consume today is ‘fake,’ as it does not provide the body with the basic components it needs to perform the chemical reactions that result in it being alive and healthy.”

The same applies to diabetes, the prevalence of which has increased 700 percent over the past 50 years and now affects one in 10 in developed countries. Research in diabetes-related issues by endocrinologist Ron Rosedale concluded the problem is basically not genetic, but linked to the radical change in lifestyle and diet that has taken place over the past half-century. An increasing amount of evidence has linked exposure to toxins with both obesity and diabetes.

Chronic digestive diseases follow a similar pattern with four out of 10 people suffering fromgut issues. A healthy gastrointestinal system is crucial. Any imbalance can affect our health negatively.

In the case of autoimmune conditions, the underlying problem is also the rapidly changing biochemistry, which results in diseased cells becoming “unidentifiable” to the immune system. Over 150 autoimmune conditions are fundamentally caused by the “body attacking itself,” a condition that is actually largely reversible by addressing precise energy blockades with the right nutritional and lifestyle protocol.

By addressing the deficiencies and overloads in a preventative manner, metabolomics can empower the body to heal itself, and prevent chronic disease that often take years, if not decades, to develop.

The other major advantage of a metabolomic panel is to attain more energy the way your body was naturally designed for, enhancing both body and brain to operate at peak levels.

Metabolomics addresses diseases such as:

  • Thyroid problems (Hashimoto, hypo- or hyper-thyroidism)
  • Gastrointestinal disorders (gastritis, gastroesophageal reflux, colitis)
  • Ulcerative colitis
  • Chron’s Disease
  • Cancer
  • Multiple Sclerosis
  • Rheumatoid arthritis
  • Osteoarthritis
  • Psoriatic arthritis
  • Ankylosing spondylitis
  • Diabetes
  • Obesity
  • Metabolic syndrome
  • Dermatological diseases (eczema, psoriasis)
  • Permeable Bowel Syndrome
  • Growth disorders
  • Autism spectrum disorders
  • Chronic Fatigue Syndrome
  • Fertility disorders
  • Allergies
  • Respiratory problems (asthma, chronic bronchitis, pulmonary fibrosis)
  • Chronic infections
  • Osteoporosis, osteopenia
  • Hormonal disorders
  • Decreased libido
  • Sleep disorders
  • Gynecological disorders (dysmenorrhea, menopause, polycystic ovary syndrome)

The Metabolomics approach does not conflict with any combined pharmaceutical or homeopathic treatment. On the contrary it improves patient’ s response, compliance and outcome while reduces any side effects that could be part of pharmacological treatments.


Root Causality

Metabolomics addresses the cause of disease. We use highly advanced analysis at a molecular and genetic (DNA) level that address the exact cause of any health problem.

Patients that reach our clinic seek to identify the real cause of their health problem and learn what they can do to improve their health.

In Metabolomic Clinic we treat patients that belong mainly in the following categories:

Autoimmune Diseases: these are diseases where the body attacks and damages its own tissues and organs such as in ulcerative colitis, multiple sclerosis, thyroid diseases, rheumatoid arthritis and others.

Chronic Health Problems: these are health problems lasting more than three months such as diabetes, gastrointestinal disorders, cancer, heart disease and more.

Prevention: addresses healthy individuals that want to maintain or improve their good health and longevity.

Metabolomic analyses can pinpoint and address the root causes for a number of individual chronic diseases such as:

Autoimmune Diseases
Heart Diseases
Neurologic Diseases
Gastrointestinal diseases
Chronic fatigue
Obesity and overweight

An analysis of over 15,000 patients shows that cells begin to weaken because of a cumulative deficit in our ability to produce and maintain energy, lack of nutrients, and an overload of toxins that affect our biochemical pathways and mitochondria. These breakdowns lead to chronic disease.

Metabolomic analyses are not similar to the routine tests usually performed since they measure small molecules at a cellular or genetic material level (DNA). They can trace hidden infections, nutritional deficiencies, metabolic imbalances, food allergies, environmental toxins, mold exposures, and also uncover underlying genetic predispositions that can be modified through diet, lifestyle, supplements or medications. Mostly of all, they uncover the real cause of any health problem. These are:

Metabolomics blood and urine tests: capture the exact state of health of the human body and can guide the treatment addressing the causal underlying problem. Metabolomic Analysis can identify data relating to the:

– lack of vitamins and other essential elements within the cells
– cellular function
– toxic burden
– antioxidant status of the organism
– functioning of the nervous system
– condition of the intestinal flora
– mitochondrial function
– metabolism of proteins, carbohydrates and fats
– existing predisposition to inflammation
– existence of acidosis or alkalosis
– essential fatty acid balance (like omega 3 and omega 6)
– insulin resistance and other vital indicators.

The treatment is formulated according to the deficiencies, dysfunctions and biochemical imbalances that have been traced through metabolomic and/or telomeres analysis. The treatment consists of the intake of special nutritional supplements, enzymes, aminoacids, trace minerals, vitamins and also a personalized nutritional plan in order to replenish the deficiencies and restore the biochemical balance in a cellular level. Pharmacological treatment maybe adapted based on the tests results. Follow up visits are be planned in 3 to 6 months based on doctor recommendations.


Metabolomics is helping to change medicine from an empirically-based therapy model to a rationalized, molecular science. This shift can be clearly seen in the distribution of Nobel laureates for medicine and physiology in the first decade of this century. There were 18 natural scientist Nobel laureates compared to only eight medical practitioners. Linus Pauling, a quantum chemist, biochemist, and one of the founders of molecular biology, could be considered the father of metabolomics. He predicted a new branch of medicine in his 1954 Nobel lecture; stating that the “chemist of the future” would come to rely on a new structural chemistry emphasizing molecular aspects. Pauling was also the founder of “orthomolecular medicine,” a branch that attributed disease to a biochemical imbalance and its treatment to proper nutrition.“The nutritional microenvironment of our body cells is crucially important to health, and deficiencies in this environment constitute a major cause of disease,” Pauling was quoted as saying.In 1971 Pauling co-authored the first paper on metabolomics although the term hadn’t yet been coined. That occurred in 1998 when it was used by S.G. Oliver and his colleagues in their published literature in Trends in Biotechnology.However, an argument could be made that modern scientists have not discovered metabolomics so much as rediscovered or renamed it.The beginning of metabolomics traces back all the way to 2000-1500 B.C. when traditional Chinese doctors began to evaluate the urine of patients to to identify high glucose levels of diabetics.More early steps toward metabolomics came in 300 B.C. when the ancient Greeks first recognized it was essential to examine body fluids (called “humor” at the time) to predict diseases. In 131 A.D., Galen, the greatest physician in ancient Rome, created a system of pathology that combined the humoral theories of Hippocrates with the Pythagorean theory.Today, metabolomics once again is emerging as a powerful tool to study metabolic processes, according to the National Center for Biotechnology Information (NCBI). Metabolomic practitioners, clinics, and applications are growing. Early metabolomic testing was used in the diagnosis of severe dengue fever in children and adults in Nicaragua and Mexico, a test supported by the National Institute of Health Grants. In 2013, UCLA established the UCLA Metabolomics Center to develop and apply cutting-edge approaches for using the findings of metabolomics medicine.The costs of metabolomic tests were prohibitive at first (up to $30.000 per test), before it was adapted for nutritional evaluation by Metabolomic Medicine, founded by Dr. Dimitris Tsoukalas in 2010 and introduced in United States in 2016.


Metabolomic Medicine was founded by Dr. Dimitris Tsoukalas, a medical doctor, researcher, educator, author, and leading expert in the application of Metabolomic Medicine in chronic and autoimmune diseases, and also the President of the European Institute of Nutritional Medicine, E.I.Nu.M.Dr. Tsoukalas is the founder of Metabolomic Medicine a complete health system that addresses the exact root causes of chronic and autoimmune diseases through the use of highly advanced cellular analysis.Dr. Tsoukalas and his team have helped thousands of people lead healthier lives. Because of his contribution in Primary Health Care, he was awarded the highest recognition and an Honorable Mention by the Greek Ministry of Health. He is the Director of the Metabolomic Medicine Switzerland AG and also President of the European Institute of Nutritional Medicine. Dr. Tsoukalas currently runs four clinics that apply Metabolomic Medicine and address autoimmune and chronic diseases in Switzerland, Italy, and Greece.Dr. Tsoukalas graduated in 1991 from the “Universita’ degli Studi di Napoli, Federico II” in Italy, being the oldest academic institution in continuous operation since 1224. In 2000 he completed his specialization in General & Family Medicine at the Hippokration University Hospital in Athens, Greece. In 2013 he completed the Harvard Medical School Update Course in General & Internal Medicine for subspecialists.Dr. Tsoukalas is a scientific adviser and has collaborated with research centers and university institutes such as the Farsight Bioscience on diabetes and metabolic diseases, with Sierra Sciences on telomere biology and the Centers for Disease Control (CDC) certified lab for metabolic disorders called Neolab.At present he is researching with the University of Crete Faculty of Medicine on metabolomics, telomere biology and effective telomere length enhancers. He is collaborating with the Zurich’s University Institute of Technology ETH on clinical applications of metabolomics.He is also collaborating with the University of Brescia Medical School Molecular Biology and Pharmacology Department regarding the use of natural antioxidant substances in neurological diseases.Through the application of metabolomic medicine, Dr. Tsoukalas helps lead athletes and national teams such as the Greek women national volleyball team, sprinters, ultra marathon runners, professional football and basketball players, and mountain Everest climbers.In conjunction with E.I.Nu.M, he created the first online course for the application of Metabolomics in Nutritional Medicine. The course awards 30 credits of Continuing Medical Education and is a vital tool that medical doctors can use to support the health of their patients.He is a bestselling author and his book How to Live 150 Years in Health is translated in three languages: English, Italian, and Greek.Over 80 doctors and nutritionists are today qualified and certified in Metabolomic Medicine worldwide.